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KMID : 0364519960080020241
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Dong-A Journal Medicine
1996 Volume.8 No. 2 p.241 ~ p.246
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Detection of Transitional Cell Carcinoma in Urine Cytology Using Immunocytochemistry of Lewis X Antigen and p53
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Abstract
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We investigated the usefulness of immunocytochemical detection of Lewis X antigen and altered p53 expression for the diagnosis of transitional cell carcinoma in urine cytology. We performed immunocytochemical stain to Lewis X antigen on 51 and
p53
on 42
urine cytology from transitional cell carcinoma patients and control, 17 urine cytology from prostatic adenocarcinoma patients, all of which are confirmed by histopathologically.
@ES The results are as follows:
@EN 1. Lewis X antigen is detected in 72.5% of urine cytology of transitional cell carcinoma of lower urinary tract (37/51) but not detected in any case of prostatic adenocarcinoma.
2. There was no relationship between Lewis X antigen expression and grade or stage of transitional cell carcinoma.
3. Altered p53 expression is detected in 30.9% of urine cytology of transitional cell carcinoma of lower urinary tract(13/42)
4. Prevalence of altered p53 expression is higher in higher grade and higher stage.
In conclusion, immunocytochemical stain to Lewis X antigen and p53 is helpful in the diagnosis of transitional cell carcinoma in urine cytology and Lewis X is more helpful than p53 to diagnose the lower grade transitional cell carcinoma.
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